Research

A list of my most recent publications is below.  See more details with my Orcid ID.

  1. Adams NBP, Brindley AA, Hunter CN, Reid JD. The catalytic power of magnesium chelatase: a benchmark for the AAA+ FEBS Letters. 2016 May 9 In press
  2. Adams NBP, Vasilev C, Brindley AA, Hunter CN. Nanomechanical and thermophoretic analyses of the nucleotide-dependent interactions between the AAA+ subunits of magnesium chelatase. J Am Chem Soc. 2016, 138 (20) 6591-7.
  3. Brindley AA, Adams NBP, Hunter CN, Reid JD. Five Glutamic Acid Residues in the C-Terminal Domain of the ChlD Subunit Play a Major Role in Conferring Mg2+ Cooperativity upon Magnesium Chelatase. Biochemistry. 2015, 54 (44) 6659-62
  4. Kopecna J, Cabeza de Vaca I, Adams NBP., Davison PA, Brindley AA, Hunter C N, Sobotka, R. Porphyrin Binding to Gun4 protein, Facilitated by a Flexible Loop, Controls Metabolite Flow through the Chlorophyll Biosynthetic Pathway. Journal of Biological Chemistry. 2015, 290 (47) 28477-88
  5. Adams NBP, Marklew CJ, Qian P, Brindley AAA, Davison PA, Bullough PA, Hunter CN. Structural and functional consequences of removing the N-terminal domain from the magnesium chelatase ChlH subunit of Thermosynechoccus elongatus. Biochem J. 2014, 464 (3) 315-22
  6. Adams NBP, Marklew CJ, Brindley AA, Hunter CN, Reid JD. Characterization of the magnesium chelatase from Thermosynechococcus elongatus. Biochem J. 2014, 457 (1) 163-70
  7. Adams NBP, Reid JD. The allosteric role of the AAA+ domain of ChlD protein from the magnesium chelatase of Synechocystis species PCC 6803. J Biol Chem. 2013, 288 (40)  28727-32.
  8. Magolan J, Adams NBP, Onozuka H, Hungerford NL, Esumi H, Coster MJ. Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation. ChemMedChem. 2012, 7 (5) 766-70.
  9. Adams NBP, Reid JD. Nonequilibrium isotope exchange reveals a catalytically significant enzyme-phosphate complex in the ATP hydrolysis pathway of the AAA+ ATPase magnesium chelatase. Biochemistry. 2012, 51 (10) 2029-31.
  10. Thomson MJ, Louth JC, Greenwood GK, Sorrell FJ, Knight SG, Adams NBP, Chen B Improved 2,4-diarythiazole-based antiprion agents: switching the sense of the amide group at C5 leads to an increase in potency. ChemMedChem, 2010, 5 (9) 1476-88
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